Which antibiotic is known to frequently cause hypersensitivity reactions?

Neomycin is well recognized for its propensity to cause hypersensitivity reactions, making it the correct choice in this context. This antibiotic belongs to the aminoglycoside class and is often used topically in ophthalmic formulations. However, it is also known for its potential to induce contact dermatitis or allergic reactions in susceptible individuals when used on the skin or in the eye.

Unlike neomycin, gentamicin and to a lesser extent, ciprofloxacin and ofloxacin, are less commonly associated with hypersensitivity reactions. While all medications can potentially cause side effects, the frequency and nature of neomycin's hypersensitivity reactions are particularly notable in clinical practice, making it important for healthcare providers to inquire about any history of allergies to neomycin before administration.