Which anti-metabolites are used for glaucoma surgery to prevent collagen production and scarring?

The correct answer involves the use of 5-Fluorouracil (5-FU) and Mitomycin C as anti-metabolites in glaucoma surgery. These agents are utilized to inhibit collagen production and prevent scarring during the healing process post-surgery.

In glaucoma procedures, especially filtering surgeries such as trabeculectomy, the goal is to create a controlled outflow of aqueous humor to lower intraocular pressure. However, excessive scarring can occur at the surgical site, leading to failure of the glaucoma surgery. By incorporating 5-FU and Mitomycin C into the surgical protocol, the proliferation of fibroblasts and subsequent collagen deposition are reduced, allowing better surgical outcomes by maintaining an adequate filtration bleb and preventing closure of the surgical site.

The other options don't serve the purpose of preventing collagen production and scarring. Acetazolamide and Isosorbide are diuretics that are used to reduce intraocular pressure but do not have a role in managing scarring. Timolol and Dorzolamide are topical medications used for lowering intraocular pressure but do not prevent scar formation in surgical procedures. Brimonidine and Bimatoprost are also medications aimed at controlling eye pressure but lack the anti-scarring